Pharma Focus America

Research Insights

The Research Insights area highlights recent advances in science and medicine as well as global laboratory research. Our readers gain tremendous benefit from research discoveries in an indirect manner.

Cellular pharmacokinetic of methotrexate and its modulation by folylpolyglutamate synthetase and γ-glutamyl hydrolase in tumor cells

Methotrexate is a folic acid analog with broadspectrum antineoplastic activity which is used in the treatment of various solid tumors

Single-cell and single-nucleus RNA-sequencing from paired normal-adenocarcinoma lung samples provide both common and discordant biological insights

Singlecell sequencing has the ability to inspect the cellular heterogeneity of tissue and cancer with unprecedented details and as such provides important insights into the cellular origin and cellspecific molecular defects

A Role for the C. Elegans Argonaute Protein CSR-1 in Small Nuclear RNA 3’ Processing

Eukaryotic RNA splicing is catalyzed by the spliceosome that removes noncoding intron segments from premRNA transcripts to produce a mature mRNA for protein translation A core component of the spliceosome is the uridylaterich small nuclear RNA

Deciphering Molecular Bridges: Unveiling the Interplay Between Metabolic Syndrome and Alzheimer’s Disease Through a Systems Biology Approach and Drug Repurposing

Alzheimers disease is a progressive neurodegenerative disorder defined by amyloid plaques and neurofibrillary tangles accumulation AD progresses from the hippocampus through the frontal and other brain regions

Identifying cellular RNA-binding proteins during infection uncovers a role for MKRN2 in influenza mRNA trafficking

In recent years our understanding of the RNAbinding protein interactome has become significantly more informed The development of methods such as RNAinteractome capture

Zmiz1 is a Novel Regulator of Lymphatic Endothelial Cell Gene Expression and Function

Lymphatic vasculature plays a crucial role in maintaining tissue fluid homeostasis facilitating lipid absorption and conducting immune surveillance The proper establishment of a functional lymphatic system is vital for embryonic

Covar: A Generalizable Machine Learning Approach to Identify the Coordinated Regulators Driving Variational Gene Expression

The advent of highthroughput genomic data acquisition techniques has generated immense interest in the statistical and datadriven analysis of biological and biochemical interactions One such approach is network inference

A Simulation-based Comparison of Drug-drug Interaction Signal Detection Methods

Polypharmacy the use of multiple medicines has increased as the average life expectancy and the prevalence of multimorbidity has increased Adverse events caused by the administration of many drugs

A Quantitative Genetic Model of Background Selection in Humans

The continual influx of new mutations into populations is the ultimate source of all adaptations but the vast majority of mutations either do not affect fitness or are deleterious Natural selection works to eliminate these deleterious

Olaparib Not Cost-effective as Maintenance Therapy for Platinum-sensitive, BRCA1/2 Germline-mutated Metastatic Pancreatic Cancer

To assess the costeffectiveness and budget impact of olaparib as a maintenance therapy in platinumresponsive metastatic pancreatic cancer patients harboring a germline BRCA mutation

Thermo Fisher Scientific - mRNA ServicesFuture Labs Live USA 2024World Vaccine Congress Europe 2024World Orphan Drug Congress 2024Advanced Therapies USA 2024World Orphan Drug Congress Europe 2024